Description:
Pain is an unpleasant but very important biological signal for danger. Nociception is necessary for survival and maintaining the integrity of the organism in a potentially hostile environment. Pain is both a sensory experience and a perceptual metaphor for damage and it is activated by noxious stimuli that act on a complex pain sensory apparatus. However, chronic pain having no more a protective role can become a ruining disease itself, termed "neuropathic pain".
This contribution throws light on the complex machinery of pain processing, from the perspective of the connections between key structures that are necessary for a profound understanding of the phenomenon of pain.
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